Anti-OPN/SPP1 antibody [SAA0512] (STJA0027662)

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STJA0027662
€318.13 - €473.13
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Host: Mouse
Applications: ELISA/FC/SPR/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Osteopontin is suitable for use in ELISA, Flow Cytometry, SPR and Western Blot research applications.
Clonality : Monoclonal
Clone ID : SAA0512
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1.2 mg/ml
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: SPP1
Gene ID: 6696
Uniprot ID: OSTP_HUMAN
Post Translational Modifications Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers, increasing its collagen binding properties. Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif. The phosphorylated form inhibits hydroxyapatite crystallization. Dephosphorylation via a mechanism involving ALPL/TNAP promotes hydroxyapatite crystallization. O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62.
Function Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
Protein Name Osteopontin
Bone Sialoprotein 1
Nephropontin
Secreted Phosphoprotein 1
Spp-1
Urinary Stone Protein
Uropontin
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-186797
Reactome: R-HSA-216083
Reactome: R-HSA-381426
Reactome: R-HSA-8949275
Reactome: R-HSA-8957275
Cellular Localisation Secreted
Alternative Antibody Names Anti-Osteopontin antibody
Anti-Bone Sialoprotein 1 antibody
Anti-Nephropontin antibody
Anti-Secreted Phosphoprotein 1 antibody
Anti-Spp-1 antibody
Anti-Urinary Stone Protein antibody
Anti-Uropontin antibody
Anti-SPP1 antibody
Anti-BNSP antibody
Anti-OPN antibody
Anti-PSEC0156 antibody

Information sourced from Uniprot.org