| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-OLIG2 (1-50) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.65µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150 IHC: 1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | OLIG2 |
| Gene ID: | 10215 |
| Uniprot ID: | OLIG2_HUMAN |
| Immunogen Region: | 1-50 |
| Immunogen: | Synthetic peptide taken within amino acid region 1-50 on human Olig2 protein. |
| Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. |
| Protein Name | Oligodendrocyte Transcription Factor 2 Oligo2 Class B Basic Helix-Loop-Helix Protein 1 Bhlhb1 Class E Basic Helix-Loop-Helix Protein 19 Bhlhe19 Protein Kinase C-Binding Protein 2 Protein Kinase C-Binding Protein Rack17 |
| Cellular Localisation | Nucleus Cytoplasm The Nls Contained In The Bhlh Domain Could Be Masked In The Native Form And Translocation To The Nucleus Could Be Mediated By Interaction Either With Class E Bhlh Partner Protein Or With Nkx2-2 |
| Alternative Antibody Names | Anti-Oligodendrocyte Transcription Factor 2 antibody Anti-Oligo2 antibody Anti-Class B Basic Helix-Loop-Helix Protein 1 antibody Anti-Bhlhb1 antibody Anti-Class E Basic Helix-Loop-Helix Protein 19 antibody Anti-Bhlhe19 antibody Anti-Protein Kinase C-Binding Protein 2 antibody Anti-Protein Kinase C-Binding Protein Rack17 antibody Anti-OLIG2 antibody Anti-BHLHB1 antibody Anti-BHLHE19 antibody Anti-PRKCBP2 antibody Anti-RACK17 antibody |
Information sourced from Uniprot.org