| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OLFM4 (211-510) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OLFM4 |
| Gene ID: |
10562 |
| Uniprot ID: |
OLFM4_HUMAN |
| Immunogen Region: |
211-510 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 211-510 of human OLFM4 (NP_006409.3). |
| Immunogen Sequence: |
AIRREIVALKTKLKECEASK DQNTPVVHPPPTPGSCGHGG VVNISKPSVVQLNWRGFSYL YGAWGRDYSPQHPNKGLYWV APLNTDGRLLEYYRLYNTLD DLLLYINARELRITYGQGSG TAVYNNNMYVNMYNTGNIAR VNLTTNTIAVTQTLPNAAYN NRFSYANVAWQDIDFAVDEN GLWVIYSTEASTGNMVISKL NDTTLQVLNTWYTKQYKPSA SNAFMVCGVLYATRTMNTR |
| Tissue Specificity | Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues. |
| Post Translational Modifications | N-glycosylated. |
| Function | May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. |
| Protein Name | Olfactomedin-4Olm4Antiapoptotic Protein Gw112G-Csf-Stimulated Clone 1 ProteinHgc-1Holfd |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceMitochondrionSubcellular Location Is Not Clearly Defined: Has Been Shown To Be SecretedBut Also In The MitochondrionCytoplasm And Plasma Membrane And In The Nucleus |
| Alternative Antibody Names | Anti-Olfactomedin-4 antibodyAnti-Olm4 antibodyAnti-Antiapoptotic Protein Gw112 antibodyAnti-G-Csf-Stimulated Clone 1 Protein antibodyAnti-Hgc-1 antibodyAnti-Holfd antibodyAnti-OLFM4 antibodyAnti-GW112 antibodyAnti-UNQ362 antibodyAnti-PRO698 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
