Anti-OLFM2 antibody (STJA0009652)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human OLFM2
General Information
| Short Description | Rabbit polyclonal anti-Noelin-2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OLFM2 |
| Gene ID | 93145 |
| Uniprot ID | NOE2_HUMAN |
| Immunogen | Synthesized peptide derived from human OLFM2 |
| Specificity | This antibody detects endogenous levels of OLFM2 at Human, Mouse |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling. |
| Protein Name | Noelin-2Olfactomedin-2 |
| Database Links | |
| Cellular Localisation | SecretedSynapseMembraneNucleusCytoplasmNuclear Localization Is Induced By Tgf-Beta |
| Alternative Antibody Names | Anti-Noelin-2 antibodyAnti-Olfactomedin-2 antibodyAnti-OLFM2 antibodyAnti-NOE2 antibody |
Information sourced from Uniprot.org