• Western blot analysis of extracts of HepG2 cells, using OGG1 antibody (STJ24861) at 1:1000 dilution. _Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. _Lysates/proteins: 25 Mu g per lane. _Blocking buffer: 3% nonfat dry milk in TBST. _Detection: ECL Enhanced Kit. _Exposure time: 90s.

Anti-OGG1 antibody (1-345) (STJ24861)

SKU:
STJ24861

£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:200-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: OGG1
Gene ID: 4968
Uniprot ID: OGG1_HUMAN
Immunogen Region: 1-345
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-345 of human OGG1 (NP_002533.1).
Immunogen Sequence: MPARALLPRRMGHRTLASTP ALWASIPCPRSELRLDLVLP SGQSFRWREQSPAHWSGVLA DQVWTLTQTEEQLHCTVYRG DKSQASRPTPDELEAVRKYF QLDVTLAQLYHHWGSVDSHF QEVAQKFQGVRLLRQDPIEC LFSFICSSNNNIARITGMVE RLCQAFGPRLIQLDDVTYHG FPSLQALAGPEVEAHLRKLG LGYRARYVSASARAILEEQG GLAWLQQLRESSYEEAHKA
Tissue Specificity Ubiquitous.
Function DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Protein Name N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site Lyase
Ap Lyase
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-110330
Reactome: R-HSA-110331
Reactome: R-HSA-110357
Reactome: R-HSA-5649702
Reactome: R-HSA-9656255
Reactome: R-HSA-9656256
Reactome: R-HSA-9657050 O15527-4
Cellular Localisation Nucleus
Nucleoplasm
Nucleus Speckle
Nucleus Matrix
Together With Apex1 Is Recruited To Nuclear Speckles In Uva-Irradiated Cells
Isoform 1a: Nucleus
Isoform 2a: Mitochondrion
Alternative Antibody Names Anti-N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site Lyase antibody
Anti-Ap Lyase antibody
Anti-OGG1 antibody
Anti-MMH antibody
Anti-MUTM antibody
Anti-OGH1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance