| Tissue Specificity | Brain, skeletal muscle, heart, kidney, lung, placenta and fibroblasts. Expressed in the retina and the retinal pigment epithelium. |
| Function | Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling. |
| Protein Name | Inositol Polyphosphate 5-Phosphatase OcrlInositol Polyphosphate 5-Phosphatase Ocrl-1Ocrl-1Lowe Oculocerebrorenal Syndrome ProteinPhosphatidylinositol 3 -4 -5-Triphosphate 5-Phosphatase |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660514Reactome: R-HSA-1855183Reactome: R-HSA-1855204Reactome: R-HSA-432722Reactome: R-HSA-8856828Reactome: R-HSA-9013409Reactome: R-HSA-9013423 |
| Cellular Localisation | Cytoplasmic VesiclePhagosome MembraneEarly Endosome MembraneMembraneClathrin-Coated PitCell ProjectionCiliumPhotoreceptor Outer SegmentEndosomeGolgi ApparatusTrans-Golgi NetworkLysosomeAlso Found On MacropinosomesColocalized With Appl1 On Phagosomes |
| Alternative Antibody Names | Anti-Inositol Polyphosphate 5-Phosphatase Ocrl antibodyAnti-Inositol Polyphosphate 5-Phosphatase Ocrl-1 antibodyAnti-Ocrl-1 antibodyAnti-Lowe Oculocerebrorenal Syndrome Protein antibodyAnti-Phosphatidylinositol 3 -4 -5-Triphosphate 5-Phosphatase antibodyAnti-OCRL antibodyAnti-OCRL1 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and OCRL knockout (KO) 293T cells, using [KO Validated] OCRL Rabbit polyclonal antibody (STJ11100852) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89786/358258/STJ11100852_1__71721.1713122596.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and OCRL knockout (KO) 293T cells, using [KO Validated] OCRL Rabbit polyclonal antibody (STJ11100852) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.")
