Anti-OCLN antibody [PT0483R] (STJA0039506)

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STJA0039506
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Host: Rabbit
Applications: WB/IHC/IF/IP/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Occludin is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Immunoprecipitation and ELISA research applications.
Clonality : Monoclonal
Clone ID : PT0483R
Conjugation: Unconjugated
Isotype: IgGk
Formulation: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification: Protein A
Dilution Range: IHC 1:200-1:1000
WB 1:2000-1:10000
IF 1:200-1:1000
ELISA 1:5000-1:20000
IP 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: OCLN
Gene ID: 100506658
Uniprot ID: OCLN_HUMAN
Specificity: Endogenous
Post Translational Modifications Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-402 reduces its ability to interact with TJP1. Phosphorylation at Ser-490 also attenuates the interaction with TJP1. (Microbial infection) Cleaved by S.pyogenes SpeB protease.leading to its degradation. Degradation by SpeB promotes bacterial translocation across the host epithelial barrier.
Function May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes.
Protein Name Occludin
Database Links Reactome: R-HSA-351906
Reactome: R-HSA-8935964
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Junction
Tight Junction
Alternative Antibody Names Anti-Occludin antibody
Anti-OCLN antibody

Information sourced from Uniprot.org

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