Anti-Occludin antibody [R08-6C4] (STJA0036225)

Name: Anti-Occludin antibody [R08-6C4] (STJA0036225)
SKU: STJA0036225
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenA synthesized peptide derived from human Occludin

STJA0036225

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Short Description	Rabbit monoclonal anti-Occludin for use in WB, IP and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IP/FC
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	R08-6C4
Isotype	IgG
Conjugation	Unconjugated
Purification	Affinity Chromatography
Dilution Range	WB 1:500-1:1000 IP 1:20 FC 1:50-1:100
Formulation	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction	Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.

Gene Symbol	OCLN
Gene ID	100506658
Uniprot ID	OCLN_HUMAN
Immunogen	A synthesized peptide derived from human Occludin

Tissue Specificity	Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
Post Translational Modifications	Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-402 reduces its ability to interact with TJP1. Phosphorylation at Ser-490 also attenuates the interaction with TJP1. (Microbial infection) Cleaved by S.pyogenes SpeB protease.leading to its degradation. Degradation by SpeB promotes bacterial translocation across the host epithelial barrier.
Function	May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes.
Protein Name	Occludin
Database Links	Reactome: R-HSA-351906 Reactome: R-HSA-8935964
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Junction Tight Junction
Alternative Antibody Names	Anti-Occludin antibody Anti-OCLN antibody

Information sourced from Uniprot.org