| Short Description : | Rabbit polyclonal anti-P protein (230-310 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | OCA2 |
| Gene ID: | 4948 |
| Uniprot ID: | P_HUMAN |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 230-310 |
| Immunogen Region: | 230-310 aa |
| Specificity: | P Polyclonal Antibody detects endogenous levels of protein. |
| Function | Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation. One of the components of the mammalian pigmentary system. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. |
| Protein Name | P ProteinMelanocyte-Specific Transporter ProteinPink-Eyed Dilution Protein Homolog |
| Database Links | Reactome: R-HSA-5662702 |
| Cellular Localisation | Melanosome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-P Protein antibodyAnti-Melanocyte-Specific Transporter Protein antibodyAnti-Pink-Eyed Dilution Protein Homolog antibodyAnti-OCA2 antibodyAnti-D15S12 antibodyAnti-P antibody |
Information sourced from Uniprot.org
