Anti-NUP62 antibody (C-Term) (STJ70481)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-NUP62 (C-Term) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
| Applications | Pep-ELISA/WB/FC |
| Host | Goat |
| Reactivity | Human/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx. 70kDa band observed in nuclear lysates of cell lines Jurkat, K562, A431 and HepG2 (calculated MW of 53.3kDa according to NP_036478.2). This molecular weight is routinely obser |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NUP62 |
| Gene ID | 23636 |
| Uniprot ID | NUP62_HUMAN |
| Accession Number | NP_036478.2; NP_057637.2; NP_714940.1; NP_714941.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | RKEQERSFRITFD |
| Specificity | All four variants represent identical protein. |
Additional Info
| Function | Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown. |
| Protein Name | Nuclear Pore Glycoprotein P6262 Kda NucleoporinNucleoporin Nup62 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-6784531Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9615933Reactome: R-HSA-9705671 |
| Cellular Localisation | NucleusNuclear Pore ComplexCytoplasmCytoskeletonSpindle PoleNucleus EnvelopeMicrotubule Organizing CenterCentrosomeCentral Region Of The Nuclear PoreWithin The TransporterDuring Mitotic Cell DivisionIt Associates With The Poles Of The Mitotic Spindle |
| Alternative Antibody Names | Anti-Nuclear Pore Glycoprotein P62 antibodyAnti-62 Kda Nucleoporin antibodyAnti-Nucleoporin Nup62 antibodyAnti-NUP62 antibody |
Information sourced from Uniprot.org