| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-NUP153 (350-450) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUP153 |
| Gene ID: | 9972 |
| Uniprot ID: | NU153_HUMAN |
| Immunogen Region: | 350-450 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human NUP153 (NP_005115.2). |
| Immunogen Sequence: | FQAKREKVDSQYPPVQRLMT PKPVSIATNRSVYFKPSLTP SGEFRKTNQRIDNKCSTGYE KNMTPGQNREQRESGFSYPN FSLPAANGLSSGVGGGGGKM R |
| Post Translational Modifications | Phosphorylated in interphase, hyperphosphorylated during mitosis. May play a role in the reversible disassembly of the nuclear pore complex during mitosis. Proteolytically degraded after poliovirus (PV) infection.degradation is partial and NCP- and TPR-binding domains withstand degradation. O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status. |
| Function | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus.in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). |
| Protein Name | Nuclear Pore Complex Protein Nup153153 Kda NucleoporinNucleoporin Nup153 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-6784531Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9705671 |
| Cellular Localisation | NucleusNucleus MembraneNuclear Pore ComplexTightly Associated With The Nuclear Membrane And LaminaLocalized To The Nucleoplasmic Side Of The Nuclear Pore Complex (Npc) Core StructureForming A Fibrous Structure Called The Nuclear BasketDissociates From The Npc Structure Early During Prophase Of MitosisIntegrated In The Newly Assembled Nuclear Envelope Of Postmitotic Cells Early In G1Colocalized With Nup98 And Tpr To The Nuclear Basket At The Nucleoplasmic Side Of The NpcDetected In Diffuse And Discrete Intranuclear FociRemained Localized To The Nuclear Membrane After Poliovirus (Pv) Infection |
| Alternative Antibody Names | Anti-Nuclear Pore Complex Protein Nup153 antibodyAnti-153 Kda Nucleoporin antibodyAnti-Nucleoporin Nup153 antibodyAnti-NUP153 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
