| Host: | Rabbit |
| Applications: | WB/IP/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM13642 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB, 1:500-1:1000IP, 0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUMB |
| Gene ID: | 8650 |
| Uniprot ID: | NUMB_HUMAN |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Immunogen Sequence: | Human |
| Function | Regulates clathrin-mediated receptor endocytosis. Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. |
| Protein Name | Protein Numb HomologH-NumbProtein S171 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-437239Reactome: R-HSA-5610780Reactome: R-HSA-5632684Reactome: R-HSA-9725554 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideEndosome MembraneLocalizes To Perinuclear Endosomes In An Aak1-Dependent Manner |
| Alternative Antibody Names | Anti-Protein Numb Homolog antibodyAnti-H-Numb antibodyAnti-Protein S171 antibodyAnti-NUMB antibodyAnti-C14orf41 antibody |
Information sourced from Uniprot.org
