Anti-NUF2 antibody (199-249 aa) (STJ193899)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human NUF2 at the amino acid range 199-249
General Information
| Short Description | Rabbit polyclonal anti-Kinetochore protein Nuf2 (199-249 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NUF2 |
| Gene ID | 83540 |
| Uniprot ID | NUF2_HUMAN |
| Immunogen | Synthesized peptide derived from the human NUF2 at the amino acid range 199-249 |
| Immunogen Region | 199-249 aa |
| Specificity | This antibody detects endogenous levels of NUF2 at Human/Mouse/Rat |
Additional Info
| Function | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. |
| Protein Name | Kinetochore Protein Nuf2Hnuf2Hnuf2rHsnuf2Cell Division Cycle-Associated Protein 1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocalizes To Kinetochores From Late Prophase To AnaphaseLocalizes Specifically To The Outer Plate Of The KinetochoreNdc80 Is Required For Efficient Kinetochore Localization |
| Alternative Antibody Names | Anti-Kinetochore Protein Nuf2 antibodyAnti-Hnuf2 antibodyAnti-Hnuf2r antibodyAnti-Hsnuf2 antibodyAnti-Cell Division Cycle-Associated Protein 1 antibodyAnti-NUF2 antibodyAnti-CDCA1 antibodyAnti-NUF2R antibody |
Information sourced from Uniprot.org