| Tissue Specificity | Widely expressed. Most abundant in liver. |
| Post Translational Modifications | Phosphorylation at Thr-45 is required for homodimer stability.dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-45 promotes the ATP-synthesis activity. |
| Function | Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. |
| Protein Name | Adp-Sugar Pyrophosphatase8-Oxo-Dgdp PhosphataseNuclear Atp-Synthesis Protein Nudix5Nucleoside Diphosphate-Linked Moiety X Motif 5Nudix Motif 5Hnudt5Ysa1h |
| Database Links | Reactome: R-HSA-2393930 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Adp-Sugar Pyrophosphatase antibodyAnti-8-Oxo-Dgdp Phosphatase antibodyAnti-Nuclear Atp-Synthesis Protein Nudix5 antibodyAnti-Nucleoside Diphosphate-Linked Moiety X Motif 5 antibodyAnti-Nudix Motif 5 antibodyAnti-Hnudt5 antibodyAnti-Ysa1h antibodyAnti-NUDT5 antibodyAnti-NUDIX5 antibodyAnti-HSPC115 antibody |
Information sourced from Uniprot.org
