| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Oxidized purine nucleoside triphosphate hydrolase (1-80 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUDT1 |
| Gene ID: | 4521 |
| Uniprot ID: | 8ODP_HUMAN |
| Immunogen Region: | 1-80 aa |
| Specificity: | 8ODP Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 1-80 |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress. |
| Protein Name | Oxidized Purine Nucleoside Triphosphate Hydrolase 2-Hydroxy-Datp Diphosphatase 7 -8-Dihydro-8-Oxoguanine Triphosphatase 8-Oxo-Dgtpase Methylated Purine Nucleoside Triphosphate Hydrolase Nucleoside Diphosphate-Linked Moiety X Motif 1 Nudix Motif 1 |
| Database Links | Reactome: R-HSA-2393930 |
| Cellular Localisation | Isoform P18: Cytoplasm Cytosol Mitochondrion Matrix Nucleus Mostly Present In Cytosol A Minor Proportion Is Mitochondrial A Very Small Amount Of The Protein Is Associated With Nuclei Isoform P26: Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Oxidized Purine Nucleoside Triphosphate Hydrolase antibody Anti-2-Hydroxy-Datp Diphosphatase antibody Anti-7 -8-Dihydro-8-Oxoguanine Triphosphatase antibody Anti-8-Oxo-Dgtpase antibody Anti-Methylated Purine Nucleoside Triphosphate Hydrolase antibody Anti-Nucleoside Diphosphate-Linked Moiety X Motif 1 antibody Anti-Nudix Motif 1 antibody Anti-NUDT1 antibody Anti-MTH1 antibody |
Information sourced from Uniprot.org