• Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-NUDT1 antibody (1-80 aa) (STJ190489)

SKU:
STJ190489

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Oxidized purine nucleoside triphosphate hydrolase (1-80 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NUDT1
Gene ID: 4521
Uniprot ID: 8ODP_HUMAN
Immunogen Region: 1-80 aa
Specificity: 8ODP Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 1-80
Post Translational Modifications The N-terminus is blocked.
Function Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.
Protein Name Oxidized Purine Nucleoside Triphosphate Hydrolase
2-Hydroxy-Datp Diphosphatase
7 -8-Dihydro-8-Oxoguanine Triphosphatase
8-Oxo-Dgtpase
Methylated Purine Nucleoside Triphosphate Hydrolase
Nucleoside Diphosphate-Linked Moiety X Motif 1
Nudix Motif 1
Database Links Reactome: R-HSA-2393930
Cellular Localisation Isoform P18: Cytoplasm
Cytosol
Mitochondrion Matrix
Nucleus
Mostly Present In Cytosol
A Minor Proportion Is Mitochondrial
A Very Small Amount Of The Protein Is Associated With Nuclei
Isoform P26: Mitochondrion Matrix
Alternative Antibody Names Anti-Oxidized Purine Nucleoside Triphosphate Hydrolase antibody
Anti-2-Hydroxy-Datp Diphosphatase antibody
Anti-7 -8-Dihydro-8-Oxoguanine Triphosphatase antibody
Anti-8-Oxo-Dgtpase antibody
Anti-Methylated Purine Nucleoside Triphosphate Hydrolase antibody
Anti-Nucleoside Diphosphate-Linked Moiety X Motif 1 antibody
Anti-Nudix Motif 1 antibody
Anti-NUDT1 antibody
Anti-MTH1 antibody

Information sourced from Uniprot.org

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