Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-NUDC (1-331) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
NUDC |
Gene ID: |
10726 |
Uniprot ID: |
NUDC_HUMAN |
Immunogen Region: |
1-331 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human NUDC (NP_006591.1). |
Immunogen Sequence: |
MGGEQEEERFDGMLLAMAQQ HEGGVQELVNTFFSFLRRKT DFFIGGEEGMAEKLITQTFS HHNQLAQKTRREKRARQEAE RREKAERAARLAKEAKSETS GPQIKELTDEEAERLQLEID QKKDAENHEAQLKNGSLDSP GKQDTEEDEEEDEKDKGKLK PNLGNGADLPNYRWTQTLSE LDLAVPFCVNFRLKGKDMVV DIQRRHLRVGLKGQPAIIDG ELYNEVKVEESSWLIEDGK |
Tissue Specificity | Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart. |
Post Translational Modifications | Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases. |
Function | Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. |
Protein Name | Nuclear Migration Protein NudcNuclear Distribution Protein C Homolog |
Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025Reactome: R-HSA-9696270 |
Cellular Localisation | CytoplasmCytoskeletonNucleusSpindleMidbodyIn A Filamentous Pattern Adjacent To The Nucleus Of Migrating Cerebellar Granule CellsColocalizes With Tubulin And Dynein And With The Microtubule Organizing CenterDistributed Throughout The Cytoplasm Of Non-Migrating CellsA Small Proportion Is NuclearIn A Punctate PatternLocalizes To The Mitotic Spindle In A Eml4-Dependent Manner |
Alternative Antibody Names | Anti-Nuclear Migration Protein Nudc antibodyAnti-Nuclear Distribution Protein C Homolog antibodyAnti-NUDC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance