| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUDC |
| Gene ID: | 10726 |
| Uniprot ID: | NUDC_HUMAN |
| Immunogen Region: | 1-331 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human NUDC (NP_006591.1). |
| Immunogen Sequence: | MGGEQEEERFDGMLLAMAQQ HEGGVQELVNTFFSFLRRKT DFFIGGEEGMAEKLITQTFS HHNQLAQKTRREKRARQEAE RREKAERAARLAKEAKSETS GPQIKELTDEEAERLQLEID QKKDAENHEAQLKNGSLDSP GKQDTEEDEEEDEKDKGKLK PNLGNGADLPNYRWTQTLSE LDLAVPFCVNFRLKGKDMVV DIQRRHLRVGLKGQPAIIDG ELYNEVKVEESSWLIEDGK |
| Tissue Specificity | Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart. |
| Post Translational Modifications | Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases. |
| Function | Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. |
| Protein Name | Nuclear Migration Protein NudcNuclear Distribution Protein C Homolog |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025Reactome: R-HSA-9696270 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusSpindleMidbodyIn A Filamentous Pattern Adjacent To The Nucleus Of Migrating Cerebellar Granule CellsColocalizes With Tubulin And Dynein And With The Microtubule Organizing CenterDistributed Throughout The Cytoplasm Of Non-Migrating CellsA Small Proportion Is NuclearIn A Punctate PatternLocalizes To The Mitotic Spindle In A Eml4-Dependent Manner |
| Alternative Antibody Names | Anti-Nuclear Migration Protein Nudc antibodyAnti-Nuclear Distribution Protein C Homolog antibodyAnti-NUDC antibody |
Information sourced from Uniprot.org