| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (28-77) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUCKS1 |
| Gene ID: | 64710 |
| Uniprot ID: | NUCKS_HUMAN |
| Immunogen Region: | 28-77 |
| Specificity: | NUCKS Polyclonal Antibody detects endogenous levels of NUCKS protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human NUCKS1. AA range:28-77 |
| Tissue Specificity | Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung. |
| Post Translational Modifications | Phosphorylated in an ATM-dependent manner in response to DNA damage. Phosphorylated by CDK1 and casein kinase. |
| Function | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1. |
| Protein Name | Nuclear Ubiquitous Casein And Cyclin-Dependent Kinase Substrate 1P1 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Nuclear Ubiquitous Casein And Cyclin-Dependent Kinase Substrate 1 antibodyAnti-P1 antibodyAnti-NUCKS1 antibodyAnti-NUCKS antibodyAnti-JC7 antibody |
Information sourced from Uniprot.org