Anti-NUAK2 antibody (479-628) (STJ11105495)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Nuak Family Snf1-Like Kinase 2 (479-628) antibody for use in IF and ICC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:50-1:200 |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NUAK2 |
| Gene ID | 81788 |
| Uniprot ID | NUAK2_HUMAN |
| Immunogen Region | 479-628 |
| Immunogen Sequence | VSGDPKEQKPPQASGLLLHR KGILKLNGKFSQTALELAAP TTFGSLDELAPPRPLARASR PSGAVSEDSILSSESFDQLD LPERLPEPPLRGCVSVDNLT GLEEPPSEGPGSCLRRWRQD PLGDSCFSLTDCQEVTATYR QALRVCSKLT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 479-628 of human NUAK2 (NP_112214.3). |
Additional Info
| Post Translational Modifications | Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylation is also possible at Thr-208. |
| Function | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway. |
| Protein Name | Nuak Family Snf1-Like Kinase 2Omphalocele Kinase 2Snf1/Amp Kinase-Related KinaseSnark |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Nuak Family Snf1-Like Kinase 2 antibodyAnti-Omphalocele Kinase 2 antibodyAnti-Snf1/Amp Kinase-Related Kinase antibodyAnti-Snark antibodyAnti-NUAK2 antibodyAnti-OMPHK2 antibodyAnti-SNARK antibody |
Information sourced from Uniprot.org