| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Endonuclease III-like protein 1 lyase is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NTHL1 |
| Gene ID: | 4913 |
| Uniprot ID: | NTH_HUMAN |
| Specificity: | NTHL1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Ubiquitinated by TRIM26.leading to proteasomal degradation. |
| Function | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. |
| Protein Name | Endonuclease Iii-Like Protein 1 Hnth1 Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase Dna Glycosylase/Ap Lyase |
| Database Links | Reactome: R-HSA-110328 Reactome: R-HSA-110329 Reactome: R-HSA-110357 Reactome: R-HSA-9630221 Reactome: R-HSA-9630222 |
| Cellular Localisation | Nucleus Mitochondrion |
| Alternative Antibody Names | Anti-Endonuclease Iii-Like Protein 1 antibody Anti-Hnth1 antibody Anti-Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase antibody Anti-Dna Glycosylase/Ap Lyase antibody Anti-NTHL1 antibody Anti-NTH1 antibody Anti-OCTS3 antibody |
Information sourced from Uniprot.org
