| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Monoclonal |
| Clone ID: | S4186RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NTHL1 |
| Gene ID: | 4913 |
| Uniprot ID: | NTH_HUMAN |
| Immunogen Region: | 1-136 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human NTH1 (NP_002519.1). |
| Immunogen Sequence: | MCSPQESGMTALSARMLTRS RSLGPGAGPRGCREEPGPLR RREAAAEARKSHSPVKRPRK AQRLRVAYEGSDSEKGEGAE PLKVPVWEPQDWQQQLVNIR AMRNKKDAPVDHLGTEHCYD SSAPPKVRRYQVLLSL |
| Tissue Specificity | Widely expressed with highest levels in heart and lowest levels in lung and liver. |
| Post Translational Modifications | Ubiquitinated by TRIM26.leading to proteasomal degradation. |
| Function | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. |
| Protein Name | Endonuclease Iii-Like Protein 1 Hnth1 Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase Dna Glycosylase/Ap Lyase |
| Database Links | Reactome: R-HSA-110328 Reactome: R-HSA-110329 Reactome: R-HSA-110357 Reactome: R-HSA-9630221 Reactome: R-HSA-9630222 |
| Cellular Localisation | Nucleus Mitochondrion |
| Alternative Antibody Names | Anti-Endonuclease Iii-Like Protein 1 antibody Anti-Hnth1 antibody Anti-Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase antibody Anti-Dna Glycosylase/Ap Lyase antibody Anti-NTHL1 antibody Anti-NTH1 antibody Anti-OCTS3 antibody |
Information sourced from Uniprot.org
