• Western blot analysis of the lysates from K562 cells using NSG1 antibody.
  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
  • Western blot analysis of lysates from COLO cells, using NSG1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using NEEP21 Polyclonal Antibody diluted at 1：2000

Anti-NSG1 antibody (112-161) (STJ94393)

SKU:
STJ94393

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Neuronal vesicle trafficking-associated protein 1 (112-161) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NSG1
Gene ID: 27065
Uniprot ID: NSG1_HUMAN
Immunogen Region: 112-161
Specificity: NEEP21 Polyclonal Antibody detects endogenous levels of NEEP21 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human NSG1. AA range:112-161
Function Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage.
Protein Name Neuronal Vesicle Trafficking-Associated Protein 1
Neuron-Enriched Endosomal Protein Of 21 Kda
Neuron-Specific Protein Family Member 1
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Golgi Apparatus
Trans-Golgi Network Membrane
Endosome Membrane
Cell Projection
Dendrite
Early Endosome Membrane
Late Endosome Membrane
Lysosome Lumen
Recycling Endosome Membrane
Cytoplasmic Vesicle Membrane
Golgi Stack Membrane
Endosome
Multivesicular Body Membrane
Endoplasmic Reticulum Membrane
Endocytosed From The Cell Surface
Thus Enters Into Early Endosomes
Trafficks To Late Endosomes And Degradates In Lysosomes
Endoplasmic Reticulum Targeting Is Essential For Apoptosis
Found In Both Stationary And Motile Endosomes
A Previous Study Supports A Type I Membrane Protein Topology
Alternative Antibody Names Anti-Neuronal Vesicle Trafficking-Associated Protein 1 antibody
Anti-Neuron-Enriched Endosomal Protein Of 21 Kda antibody
Anti-Neuron-Specific Protein Family Member 1 antibody
Anti-NSG1 antibody
Anti-D4S234 antibody
Anti-NEEP21 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance