Anti-NSFL1C antibody (STJA0007189)

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STJA0007189
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-NSFL1 cofactor p47 is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NSFL1C
Gene ID: 55968
Uniprot ID: NSF1C_HUMAN
Specificity: This antibody detects endogenous levels of NSFL1C at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human NSFL1C
Function Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Protein Name Nsfl1 Cofactor P47
Ubx Domain-Containing Protein 2c
P97 Cofactor P47
Database Links Reactome: R-HSA-9013407
Cellular Localisation Nucleus
Golgi Apparatus
Golgi Stack
Chromosome
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Predominantly Nuclear In Interphase Cells
Bound To The Axial Elements Of Sex Chromosomes In Pachytene Spermatocytes
A Small Proportion Of The Protein Is Cytoplasmic
Associated With Golgi Stacks
Localizes To Centrosome During Mitotic Prophase And Metaphase
Alternative Antibody Names Anti-Nsfl1 Cofactor P47 antibody
Anti-Ubx Domain-Containing Protein 2c antibody
Anti-P97 Cofactor P47 antibody
Anti-NSFL1C antibody
Anti-UBXN2C antibody

Information sourced from Uniprot.org

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