Anti-NRXN3 antibody (30-110) (STJ94422)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from Neurexin III Beta. at AA range: 30-110
General Information
| Short Description | Rabbit polyclonal anti-Neurexin-3-beta (30-110) for use in WB, ELISA and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NRXN3 |
| Gene ID | 9369 |
| Uniprot ID | NRX3B_HUMAN |
| Immunogen | Synthesized peptide derived from Neurexin III Beta. at AA range: 30-110 |
| Immunogen Region | 30-110 |
| Specificity | Neurexin III Beta Polyclonal Antibody detects endogenous levels of Neurexin III Beta protein. |
Additional Info
| Tissue Specificity | Expressed in the blood vessel walls (at protein level). |
| Post Translational Modifications | Processed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides. O-glycosylated.contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins. |
| Function | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response. |
| Protein Name | Neurexin-3-BetaNeurexin Iii-Beta Cleaved Into - Neurexin-3-Beta - Soluble Form - Neurexin-3-Beta - C-Terminal FragmentNrxn3-Ctf |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Presynaptic Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Neurexin-3-Beta antibodyAnti-Neurexin Iii-Beta Cleaved Into - Neurexin-3-Beta - Soluble Form - Neurexin-3-Beta - C-Terminal Fragment antibodyAnti-Nrxn3-Ctf antibodyAnti-NRXN3 antibodyAnti-KIAA0743 antibody |
Information sourced from Uniprot.org