| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NRP1 |
| Gene ID: | 8829 |
| Uniprot ID: | NRP1_HUMAN |
| Immunogen Region: | 901-923 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 824-923 of human Neuropilin-1 (NRP1) (NP_003864.5). |
| Immunogen Sequence: | IDETGSTPGYEGEGEGDKNI SRKPGNVLKTLDPILITIIA MSALGVLLGAVCGVVLYCAC WHNGMSERNLSALENYNFEL VDGVKLKKDKLNTQSTYSEA |
| Tissue Specificity | Isoform 1: The expression of isoforms 1 and 2 does not seem to overlap. Expressed in olfactory epithelium (at protein level). Expressed in fibroblasts (at protein level). Expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta.moderately in lung, liver, skeletal muscle, kidney and pancreas.and low in adult brain. Expressed in the central nervous system, including olfactory related regions such as the olfactory tubercles and paraolfactory gyri. Isoform 2: The expression of isoforms 1 and 2 does not seem to overlap. Found in liver hepatocytes, kidney distal and proximal tubules. |
| Function | Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR. (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection. Isoform 2: Binds VEGF-165 and may inhibit its binding to cells. May induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. |
| Protein Name | Neuropilin-1 Vascular Endothelial Cell Growth Factor 165 Receptor Cd Antigen Cd304 |
| Database Links | Reactome: R-HSA-194306 Reactome: R-HSA-376176 Reactome: R-HSA-399954 Reactome: R-HSA-399955 Reactome: R-HSA-399956 Reactome: R-HSA-445144 Reactome: R-HSA-447041 Reactome: R-HSA-9694614 |
| Cellular Localisation | Isoform 2: Secreted Mitochondrion Membrane Single-Pass Type I Membrane Protein Cell Membrane Cytoplasm |
| Alternative Antibody Names | Anti-Neuropilin-1 antibody Anti-Vascular Endothelial Cell Growth Factor 165 Receptor antibody Anti-Cd Antigen Cd304 antibody Anti-NRP1 antibody Anti-NRP antibody Anti-VEGF165R antibody |
Information sourced from Uniprot.org