• Western blot analysis of lysate from 293 cells, using NRP1 Antibody.
  • Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:100
  • Western blot analysis of 293 cells using Neuropilin Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-NRP1 antibody (321-370 aa) (STJ96817)

SKU:
STJ96817

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Neuropilin-1 (321-370 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NRP1
Gene ID: 8829
Uniprot ID: NRP1_HUMAN
Immunogen Region: 321-370 aa
Specificity: Neuropilin Polyclonal Antibody detects endogenous levels of Neuropilin protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NRP1 at the amino acid range 321-370
Function Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR. (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection. Isoform 2: Binds VEGF-165 and may inhibit its binding to cells. May induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Protein Name Neuropilin-1
Vascular Endothelial Cell Growth Factor 165 Receptor
Cd Antigen Cd304
Database Links Reactome: R-HSA-194306
Reactome: R-HSA-376176
Reactome: R-HSA-399954
Reactome: R-HSA-399955
Reactome: R-HSA-399956
Reactome: R-HSA-445144
Reactome: R-HSA-447041
Reactome: R-HSA-9694614
Cellular Localisation Isoform 2: Secreted
Mitochondrion Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Cytoplasm
Alternative Antibody Names Anti-Neuropilin-1 antibody
Anti-Vascular Endothelial Cell Growth Factor 165 Receptor antibody
Anti-Cd Antigen Cd304 antibody
Anti-NRP1 antibody
Anti-NRP antibody
Anti-VEGF165R antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance