| Short Description : | Rabbit polyclonal anti-Neural retina-specific leucine zipper protein (19-68) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000ELISA 1:10000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NRL |
| Gene ID: | 4901 |
| Uniprot ID: | NRL_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human NRL. AA range:19-68 |
| Immunogen Region: | 19-68 |
| Specificity: | Nrl Polyclonal Antibody detects endogenous levels of Nrl protein. |
| Tissue Specificity | Expressed in the brain and the retina. Expressed strongly in rod and cone cells (at protein level). |
| Post Translational Modifications | Phosphorylated. Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation. |
| Function | Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds to the rhodopsin promoter in a sequence-specific manner. |
| Protein Name | Neural Retina-Specific Leucine Zipper ProteinNrl |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Neural Retina-Specific Leucine Zipper Protein antibodyAnti-Nrl antibodyAnti-NRL antibodyAnti-D14S46E antibody |
Information sourced from Uniprot.org
