Anti-NRD1 antibody (160-400) (STJ111579)

Name: Anti-NRD1 antibody (160-400) (STJ111579)
SKU: STJ111579
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ111579

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Short Description	Rabbit polyclonal NRD1 (160-400) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	NRDC
Gene ID	4898
Uniprot ID	NRDC_HUMAN
Immunogen Region	160-400
Immunogen Sequence	SGAEIEDDDEEGFDDEDEFD DEHDDDLDTEDNELEELEER AEARKKTTEKQSAAALCVGV GSFADPDDLPGLAHFLEHMV FMGSLKYPDENGFDAFLKKH GGSDNASTDCERTVFQFDVQ RKYFKEALDRWAQFFIHPLM IRDAIDREVEAVDSEYQLAR PSDANRKEMLFGSLARPGHP MGKFFWGNAETLKHEPRKNN IDTHARLREFWMRYYSSHYM TLVVQSKETLDTLEKWVTE
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human NRD1 (NP_001095132.1).

Tissue Specificity	Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.
Function	Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH).
Protein Name	Nardilysin N-Arginine Dibasic Convertase Nrd Convertase Nrd-C Nardilysin Convertase
Database Links
Cellular Localisation	Mitochondrion Cell Projection Dendrite
Alternative Antibody Names	Anti-Nardilysin antibody Anti-N-Arginine Dibasic Convertase antibody Anti-Nrd Convertase antibody Anti-Nrd-C antibody Anti-Nardilysin Convertase antibody Anti-NRDC antibody Anti-NRD1 antibody

Information sourced from Uniprot.org