| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NRD1 (160-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NRDC |
| Gene ID: |
4898 |
| Uniprot ID: |
NRDC_HUMAN |
| Immunogen Region: |
160-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human NRD1 (NP_001095132.1). |
| Immunogen Sequence: |
SGAEIEDDDEEGFDDEDEFD DEHDDDLDTEDNELEELEER AEARKKTTEKQSAAALCVGV GSFADPDDLPGLAHFLEHMV FMGSLKYPDENGFDAFLKKH GGSDNASTDCERTVFQFDVQ RKYFKEALDRWAQFFIHPLM IRDAIDREVEAVDSEYQLAR PSDANRKEMLFGSLARPGHP MGKFFWGNAETLKHEPRKNN IDTHARLREFWMRYYSSHYM TLVVQSKETLDTLEKWVTE |
| Tissue Specificity | Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues. |
| Function | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH). |
| Protein Name | NardilysinN-Arginine Dibasic ConvertaseNrd ConvertaseNrd-CNardilysin Convertase |
| Cellular Localisation | MitochondrionCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Nardilysin antibodyAnti-N-Arginine Dibasic Convertase antibodyAnti-Nrd Convertase antibodyAnti-Nrd-C antibodyAnti-Nardilysin Convertase antibodyAnti-NRDC antibodyAnti-NRD1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and NRD1 knockout (KO) 293T cells, using [KO Validated] NRD1 Rabbit polyclonal antibody (STJ11100733) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89671/358166/STJ11100733_1__46368.1713122470.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and NRD1 knockout (KO) 293T cells, using [KO Validated] NRD1 Rabbit polyclonal antibody (STJ11100733) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
