| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NRDC |
| Gene ID: | 4898 |
| Uniprot ID: | NRDC_HUMAN |
| Immunogen Region: | 160-400 |
| Immunogen Sequence: | SGAEIEDDDEEGFDDEDEFD DEHDDDLDTEDNELEELEER AEARKKTTEKQSAAALCVGV GSFADPDDLPGLAHFLEHMV FMGSLKYPDENGFDAFLKKH GGSDNASTDCERTVFQFDVQ RKYFKEALDRWAQFFIHPLM IRDAIDREVEAVDSEYQLAR PSDANRKEMLFGSLARPGHP MGKFFWGNAETLKHEPRKNN IDTHARLREFWMRYYSSHYM TLVVQSKETLDTLEKWVTE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human NRD1 (NP_001095132.1). |
| Tissue Specificity | Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues. |
| Function | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH). |
| Protein Name | NardilysinN-Arginine Dibasic ConvertaseNrd ConvertaseNrd-CNardilysin Convertase |
| Database Links | |
| Cellular Localisation | MitochondrionCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Nardilysin antibodyAnti-N-Arginine Dibasic Convertase antibodyAnti-Nrd Convertase antibodyAnti-Nrd-C antibodyAnti-Nardilysin Convertase antibodyAnti-NRDC antibodyAnti-NRD1 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and NRD1 knockout (KO) 293T cells, using [KO Validated] NRD1 Rabbit polyclonal antibody (STJ11100733) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89671/358166/STJ11100733_1__46368.1713122470.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and NRD1 knockout (KO) 293T cells, using [KO Validated] NRD1 Rabbit polyclonal antibody (STJ11100733) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
