• Western blot analysis of lysates from wild type (WT) and NRD1 knockout (KO) 293T cells, using [KO Validated] NRD1 Rabbit polyclonal antibody (STJ11100733) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-NRD1 antibody (160-400) (STJ11100733)

SKU:
STJ11100733

£129.50 - £639.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NRD1 (160-400) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:200-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NRDC
Gene ID: 4898
Uniprot ID: NRDC_HUMAN
Immunogen Region: 160-400
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human NRD1 (NP_001095132.1).
Immunogen Sequence: SGAEIEDDDEEGFDDEDEFD DEHDDDLDTEDNELEELEER AEARKKTTEKQSAAALCVGV GSFADPDDLPGLAHFLEHMV FMGSLKYPDENGFDAFLKKH GGSDNASTDCERTVFQFDVQ RKYFKEALDRWAQFFIHPLM IRDAIDREVEAVDSEYQLAR PSDANRKEMLFGSLARPGHP MGKFFWGNAETLKHEPRKNN IDTHARLREFWMRYYSSHYM TLVVQSKETLDTLEKWVTE
Tissue Specificity Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.
Function Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH).
Protein Name Nardilysin
N-Arginine Dibasic Convertase
Nrd Convertase
Nrd-C
Nardilysin Convertase
Cellular Localisation Mitochondrion
Cell Projection
Dendrite
Alternative Antibody Names Anti-Nardilysin antibody
Anti-N-Arginine Dibasic Convertase antibody
Anti-Nrd Convertase antibody
Anti-Nrd-C antibody
Anti-Nardilysin Convertase antibody
Anti-NRDC antibody
Anti-NRD1 antibody

Information sourced from Uniprot.org

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