| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-NR4A2 (566-591) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.61 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:50-1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | NR4A2 |
| Gene ID: | 4929 |
| Uniprot ID: | NR4A2_HUMAN |
| Immunogen Region: | 566-591 |
| Immunogen: | Synthetic peptide corresponding to amino acid region 566-591. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker. |
| Tissue Specificity | Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. |
| Function | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. |
| Protein Name | Nuclear Receptor Subfamily 4 Group A Member 2Immediate-Early Response Protein NotOrphan Nuclear Receptor Nurr1Transcriptionally-Inducible Nuclear Receptor |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | CytoplasmNucleusMostly NuclearOxidative Stress Promotes Cytoplasmic Localization |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 4 Group A Member 2 antibodyAnti-Immediate-Early Response Protein Not antibodyAnti-Orphan Nuclear Receptor Nurr1 antibodyAnti-Transcriptionally-Inducible Nuclear Receptor antibodyAnti-NR4A2 antibodyAnti-NOT antibodyAnti-NURR1 antibodyAnti-TINUR antibody |
Information sourced from Uniprot.org
