| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Nuclear receptor subfamily 2 group C member 1 (40-120 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NR2C1 |
| Gene ID: |
7181 |
| Uniprot ID: |
NR2C1_HUMAN |
| Immunogen Region: |
40-120 aa |
| Specificity: |
NR2C1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 40-120 |
| Function | Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. |
| Protein Name | Nuclear Receptor Subfamily 2 Group C Member 1Orphan Nuclear Receptor Tr2Testicular Receptor 2 |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | NucleusPml BodyRecruited By Hdac3After All-Trans Retinoic Acid Stimulated Mapk1-Mediated Thr-223 PhosphorylationTo Pml Bodies For Subsequent Sumoylation |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 2 Group C Member 1 antibodyAnti-Orphan Nuclear Receptor Tr2 antibodyAnti-Testicular Receptor 2 antibodyAnti-NR2C1 antibodyAnti-TR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
