NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-β/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer CARCINOGENESIS Jin Wang IHC, WB mouse, Human BxPC-3 cell-Xenograft PANC-1 cells, BxPC-3 cells

Anti-NR2C1 antibody (40-120 aa) (STJ190193)

SKU:
STJ190193
£48.00 - £252.00
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Nuclear receptor subfamily 2 group C member 1 (40-120 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NR2C1
Gene ID: 7181
Uniprot ID: NR2C1_HUMAN
Immunogen Region: 40-120 aa
Specificity: NR2C1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 40-120
Function Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Protein Name Nuclear Receptor Subfamily 2 Group C Member 1
Orphan Nuclear Receptor Tr2
Testicular Receptor 2
Database Links Reactome: R-HSA-383280
Reactome: R-HSA-4090294
Cellular Localisation Nucleus
Pml Body
Recruited By Hdac3
After All-Trans Retinoic Acid Stimulated Mapk1-Mediated Thr-223 Phosphorylation
To Pml Bodies For Subsequent Sumoylation
Alternative Antibody Names Anti-Nuclear Receptor Subfamily 2 Group C Member 1 antibody
Anti-Orphan Nuclear Receptor Tr2 antibody
Anti-Testicular Receptor 2 antibody
Anti-NR2C1 antibody
Anti-TR2 antibody

Information sourced from Uniprot.org

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