| Host: |
Rabbit |
| Applications: |
CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NPR1 (1042-1057) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.85 µg/µl |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:25-1:250ICC: 1:25-1:250IF: 1:25-1:250CFM: 1:25-1:250 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
NPR1 |
| Gene ID: |
4881 |
| Uniprot ID: |
ANPRA_HUMAN |
| Immunogen Region: |
1042-1057 |
| Specificity: |
Will label a 127 to 130 kDa protein in various tissues. Will label only PGCA, but not other Particulate Guanylate Cyclases. |
| Immunogen: |
Synthetic peptide corresponding to C terminal amino acids 1042-1057 of Human PGCA. Seqence: VRTYWLLGERGCSTRG |
| Post Translational Modifications | Phosphorylation of the protein kinase-like domain is required for full activation by ANP. |
| Function | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. |
| Protein Name | Atrial Natriuretic Peptide Receptor 1Atrial Natriuretic Peptide Receptor Type AAnp-AAnpr-ANpr-AGuanylate Cyclase AGc-A |
| Database Links | Reactome: R-HSA-5578768 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Atrial Natriuretic Peptide Receptor 1 antibodyAnti-Atrial Natriuretic Peptide Receptor Type A antibodyAnti-Anp-A antibodyAnti-Anpr-A antibodyAnti-Npr-A antibodyAnti-Guanylate Cyclase A antibodyAnti-Gc-A antibodyAnti-NPR1 antibodyAnti-ANPRA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
