Anti-NPHP3 antibody (1092-1142 aa) (STJ195126)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human NPHP3 at the amino acid range 1092-1142
General Information
| Short Description | Rabbit polyclonal anti-Nephrocystin-3 (1092-1142 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NPHP3 |
| Gene ID | 27031 |
| Uniprot ID | NPHP3_HUMAN |
| Immunogen | Synthesized peptide derived from the human NPHP3 at the amino acid range 1092-1142 |
| Immunogen Region | 1092-1142 aa |
| Specificity | This antibody detects endogenous levels of NPHP3 at Human/Mouse |
Additional Info
| Function | Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. |
| Protein Name | Nephrocystin-3 |
| Database Links | Reactome: R-HSA-5624138 |
| Cellular Localisation | Cell ProjectionCiliumLocalization To Cilium Is Mediated Via Interaction With Unc119 And Unc119bWhich Bind To The Myristoyl Moiety Of The N-Terminus |
| Alternative Antibody Names | Anti-Nephrocystin-3 antibodyAnti-NPHP3 antibodyAnti-KIAA2000 antibody |
Information sourced from Uniprot.org