| Post Translational Modifications | Highly glycosylated. |
| Function | Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. |
| Protein Name | Npc1-Like Intracellular Cholesterol Transporter 1Niemann-Pick C1-Like Protein 1 |
| Database Links | Reactome: R-RNO-8963678 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneSubfractionation Of Brush Border Membranes From Proximal Enterocytes Suggests Considerable Association With The Apical Membrane FractionExists As A Predominantly Cell Surface Membrane Expressed Protein |
| Alternative Antibody Names | Anti-Npc1-Like Intracellular Cholesterol Transporter 1 antibodyAnti-Niemann-Pick C1-Like Protein 1 antibodyAnti-Npc1l1 antibody |
Information sourced from Uniprot.org
