| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Npc1l1-Mouse (56-69) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: |
56-69 |
| Accession Number: |
NP_997125.2 |
| Immunogen Sequence: |
CLSNTPARHVTGDH |
| Post Translational Modifications | Highly glycosylated. |
| Function | Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. |
| Protein Name | Npc1-Like Intracellular Cholesterol Transporter 1Niemann-Pick C1-Like Protein 1 |
| Database Links | Reactome: R-RNO-8963678 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneSubfractionation Of Brush Border Membranes From Proximal Enterocytes Suggests Considerable Association With The Apical Membrane FractionExists As A Predominantly Cell Surface Membrane Expressed Protein |
| Alternative Antibody Names | Anti-Npc1-Like Intracellular Cholesterol Transporter 1 antibodyAnti-Niemann-Pick C1-Like Protein 1 antibodyAnti-Npc1l1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
