| Post Translational Modifications | Isoform v2: Phosphorylation at Ser-475 by CaMK2 and at Ser-490, Thr-494 and Ser-498 by PKC/PRKCA positively regulates its catalytic activity. Isoform v2: S-nitrosylation in response to nitric oxide inhibits its catalytic activity. |
| Function | Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. May play a role in cell growth and apoptosis. Isoform v2: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. Isoform v1: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Isoform v5: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. lacks enzyme activity. Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. Isoform v4: Lacks calcium-dependent NADPH oxidase activity. Isoform v3: Lacks calcium-dependent NADPH oxidase activity. |
| Protein Name | Nadph Oxidase 5 |
| Database Links | Reactome: R-HSA-3299685 |
| Cellular Localisation | Isoform V2: Endoplasmic ReticulumCell MembraneMulti-Pass Membrane ProteinCalcium-Sensitive Association And Dissociation Between The N- And C-Terminal Domains Appears To Facilitate Its Localization To The Cell MembraneIsoform V5: Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Nadph Oxidase 5 antibodyAnti-NOX5 antibody |
Information sourced from Uniprot.org
