Anti-NOS3 antibody (C-Term) [M221] (STJA0005488)

SKU:
STJA0005488-100

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Host: Mouse
Applications: WB/ICC/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-eNOS (C-Term) is suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: M221
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
IHC 1:200
ICC 1:50
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Nos3
Gene ID: 18127
Uniprot ID: NOS3_MOUSE
Immunogen Region: C-Term
Specificity: The antibody detects a 140 kDa* protein corresponding to eNOS on SDS-PAGE immunoblots of human umbilical vein endothelial cells.
Immunogen: Clone (M221) was generated from a recombinant mouse eNOS protein that included amino acids residues in the C-terminal region. This sequence is conserved in human and rat eNOS, and has low homology to other NOS family members.
Function Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. May play a significant role in normal and abnormal limb development.
Protein Name Nitric Oxide Synthase 3
Constitutive Nos
Cnos
Ec-Nos
Nos Type Iii
Nosiii
Nitric Oxide Synthase - Endothelial
Endothelial Nos
Enos
Database Links Reactome: R-MMU-1222556
Reactome: -MMU-1474151
Reactome: -MMU-203615
Reactome: -MMU-203641
Reactome: -MMU-203754
Reactome: -MMU-392154
Reactome: -MMU-5218920
Reactome: -MMU-9009391
Cellular Localisation Membrane
Caveola
Cytoplasm
Cytoskeleton
Golgi Apparatus
Cell Membrane
Specifically Associates With Actin Cytoskeleton In The G2 Phase Of The Cell Cycle
Which Is Favored By Interaction With Nosip And Results In A Reduced Enzymatic Activity
Alternative Antibody Names Anti-Nitric Oxide Synthase 3 antibody
Anti-Constitutive Nos antibody
Anti-Cnos antibody
Anti-Ec-Nos antibody
Anti-Nos Type Iii antibody
Anti-Nosiii antibody
Anti-Nitric Oxide Synthase - Endothelial antibody
Anti-Endothelial Nos antibody
Anti-Enos antibody
Anti-Nos3 antibody
Anti-Ecnos antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance