| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Nucleolar protein 58 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NOP58 |
| Gene ID: | 51602 |
| Uniprot ID: | NOP58_HUMAN |
| Specificity: | This antibody detects endogenous levels of NOP58 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human NOP58 |
| Post Translational Modifications | Sumoylation is essential for high-affinity binding to snoRNAs. |
| Function | Required for 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | Nucleolar Protein 58 Nucleolar Protein 5 |
| Database Links | Reactome: R-HSA-4570464 Reactome: R-HSA-6790901 Reactome: R-HSA-6791226 |
| Cellular Localisation | Nucleus Nucleolus Nucleoplasm Localizes To The Nucleolus With A Minor Part Present In The Nucleoplasm |
| Alternative Antibody Names | Anti-Nucleolar Protein 58 antibody Anti-Nucleolar Protein 5 antibody Anti-NOP58 antibody Anti-NOL5 antibody Anti-NOP5 antibody Anti-HSPC120 antibody |
Information sourced from Uniprot.org