| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Sumoylation is essential for high-affinity binding to snoRNAs. |
| Function | Required for 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | Nucleolar Protein 58Nucleolar Protein 5 |
| Database Links | Reactome: R-HSA-4570464Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusNucleoplasmLocalizes To The Nucleolus With A Minor Part Present In The Nucleoplasm |
| Alternative Antibody Names | Anti-Nucleolar Protein 58 antibodyAnti-Nucleolar Protein 5 antibodyAnti-NOP58 antibodyAnti-NOL5 antibodyAnti-NOP5 antibodyAnti-HSPC120 antibody |
Information sourced from Uniprot.org
