| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NOP58 (360-529) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NOP58 |
| Gene ID: |
51602 |
| Uniprot ID: |
NOP58_HUMAN |
| Immunogen Region: |
360-529 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 360-529 of human NOP58 (NP_057018.1). |
| Immunogen Sequence: |
RMLAAKTVLAIRYDAFGEDS SSAMGVENRAKLEARLRTLE DRGIRKISGTGKALAKTEKY EHKSEVKTYDPSGDSTLPTC SKKRKIEQVDKEDEITEKKA KKAKIKVKVEEEEEEKVAEE EETSVKKKKKRGKKKHIKEE PLSEEEPCTSTAIASPEKKK KKKKKRENED |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Sumoylation is essential for high-affinity binding to snoRNAs. |
| Function | Required for 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | Nucleolar Protein 58Nucleolar Protein 5 |
| Database Links | Reactome: R-HSA-4570464Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusNucleoplasmLocalizes To The Nucleolus With A Minor Part Present In The Nucleoplasm |
| Alternative Antibody Names | Anti-Nucleolar Protein 58 antibodyAnti-Nucleolar Protein 5 antibodyAnti-NOP58 antibodyAnti-NOL5 antibodyAnti-NOP5 antibodyAnti-HSPC120 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
