Anti-NOP56 antibody (1-160) (STJ11101485)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NOP56 (1-160) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NOP56 |
| Gene ID | 10528 |
| Uniprot ID | NOP56_HUMAN |
| Immunogen Region | 1-160 |
| Immunogen Sequence | MVLLHVLFEHAVGYALLALK EVEEISLLQPQVEESVLNLG KFHSIVRLVAFCPFASSQVA LENANAVSEGVVHEDLRLLL ETHLPSKKKKVLLGVGDPKI GAAIQEELGYNCQTGGVIAE ILRGVRLHFHNLVKGLTDLS ACKAQLGLGHSYSRAKVKFN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human NOP56 (NP_006383.2). |
Additional Info
| Function | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs). |
| Protein Name | Nucleolar Protein 56Nucleolar Protein 5a |
| Database Links | Reactome: R-HSA-390471Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusCytoplasmNucleoplasm |
| Alternative Antibody Names | Anti-Nucleolar Protein 56 antibodyAnti-Nucleolar Protein 5a antibodyAnti-NOP56 antibodyAnti-NOL5A antibody |
Information sourced from Uniprot.org