| Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. Required for efficient rRNA processing and 60S ribosomal subunit biogenesis. Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. |
| Protein Name | 28s RrnaCytosine(4447-C(5-MethyltransferaseNucleolar Protein 1Nucleolar Protein 2 HomologProliferating-Cell Nucleolar Antigen P120Proliferation-Associated Nucleolar Protein P120 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-8869496 |
| Cellular Localisation | NucleusNucleolusLocalizes Predominantly In The Nucleolus And To A Smaller Extent In The Nucleus |
| Alternative Antibody Names | Anti-28s Rrna antibodyAnti-Cytosine(4447-C(5-Methyltransferase antibodyAnti-Nucleolar Protein 1 antibodyAnti-Nucleolar Protein 2 Homolog antibodyAnti-Proliferating-Cell Nucleolar Antigen P120 antibodyAnti-Proliferation-Associated Nucleolar Protein P120 antibodyAnti-NOP2 antibodyAnti-NOL1 antibodyAnti-NSUN1 antibody |
Information sourced from Uniprot.org
