| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NOP2 |
| Gene ID: |
4839 |
| Uniprot ID: |
NOP2_HUMAN |
| Immunogen Region: |
355-590 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 355-590 of human NOP2 (NP_001245237.1). |
| Immunogen Sequence: |
IGATPEYLAGHYMLQGASSM LPVMALAPQEHERILDMCCA PGGKTSYMAQLMKNTGVILA NDANAERLKSVVGNLHRLGV TNTIISHYDGRQFPKVVGGF DRVLLDAPCSGTGVISKDPA VKTNKDEKDILRCAHLQKEL LLSAIDSVNATSKTGGYLVY CTCSITVEENEWVVDYALKK RNVRLVPTGLDFGQEGFTRF RERRFHPSLRSTRRFYPHTH NMDGFFIAKFKKFSNS |
| Post Translational Modifications | Citrullinated by PADI4. |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. Required for efficient rRNA processing and 60S ribosomal subunit biogenesis. Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. |
| Protein Name | 28s RrnaCytosine(4447-C(5-MethyltransferaseNucleolar Protein 1Nucleolar Protein 2 HomologProliferating-Cell Nucleolar Antigen P120Proliferation-Associated Nucleolar Protein P120 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-8869496 |
| Cellular Localisation | NucleusNucleolusLocalizes Predominantly In The Nucleolus And To A Smaller Extent In The Nucleus |
| Alternative Antibody Names | Anti-28s Rrna antibodyAnti-Cytosine(4447-C(5-Methyltransferase antibodyAnti-Nucleolar Protein 1 antibodyAnti-Nucleolar Protein 2 Homolog antibodyAnti-Proliferating-Cell Nucleolar Antigen P120 antibodyAnti-Proliferation-Associated Nucleolar Protein P120 antibodyAnti-NOP2 antibodyAnti-NOL1 antibodyAnti-NSUN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
