| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NOL12 |
| Gene ID: | 79159 |
| Uniprot ID: | NOL12_HUMAN |
| Immunogen Region: | 1-213 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human NOL12 (NP_077289.1). |
| Immunogen Sequence: | MGRNKKKKRDGDDRRPRLVL SFDEEKRREYLTGFHKRKVE RKKAAIEEIKQRLKEEQRKL REERHQEYLKMLAEREEALE EADELDRLVTAKTESVQYDH PNHTVTVTTISDLDLSGARL LGLTPPEGGAGDRSEEEASS TEKPTKALPRKSRDPLLSQR ISSLTASLHAHSRKKVKRKH PRRAQDSKKPPRAPRTSKAQ RRRLTGKARHSGE |
| Function | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Plays also a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. |
| Protein Name | Nucleolar Protein 12 |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusCytoplasm |
| Alternative Antibody Names | Anti-Nucleolar Protein 12 antibodyAnti-NOL12 antibody |
Information sourced from Uniprot.org