Anti-NMU antibody (35-174) (STJ116312)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NMU (35-174) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NMU |
| Gene ID | 10874 |
| Uniprot ID | NMU_HUMAN |
| Immunogen Region | 35-174 |
| Immunogen Sequence | ACRGAPILPQGLQPEQQLQL WNEIDDTCSSFLSIDSQPQA SNALEELCFMIMGMLPKPQE QDEKDNTKRFLFHYSKTQKL GKSNVVSSVVHPLLQLVPHL HERRMKRFRVDEEFQSPFAS QSRGYFLFRPRNGRRSAGFI |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 35-174 of human NMU (NP_006672.1). |
Additional Info
| Tissue Specificity | Expressed throughout the enteric nervous system with highest levels being found in the jejunum. |
| Function | Neuromedin-U-25: Ligand for receptors NMUR1 and NMUR2. Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Neuromedin precursor-related peptide 33: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. Neuromedin precursor-related peptide 36: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. |
| Protein Name | Neuromedin-U Cleaved Into - Neuromedin Precursor-Related Peptide 36Nurp36 - Neuromedin Precursor-Related Peptide 33Nurp33 - Neuromedin-U-25Nmu-25 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Neuromedin-U Cleaved Into - Neuromedin Precursor-Related Peptide 36 antibodyAnti-Nurp36 - Neuromedin Precursor-Related Peptide 33 antibodyAnti-Nurp33 - Neuromedin-U-25 antibodyAnti-Nmu-25 antibodyAnti-NMU antibody |
Information sourced from Uniprot.org