| Tissue Specificity | Widely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain. |
| Function | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form.nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following mechanical or toxic insults. Neural protection does not correlate with cellular NAD(+) levels but may still require enzyme activity. |
| Protein Name | Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 1Nmn/Namn Adenylyltransferase 1Nicotinamide-Nucleotide Adenylyltransferase 1Nmn Adenylyltransferase 1Nicotinate-Nucleotide Adenylyltransferase 1Namn Adenylyltransferase 1 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 1 antibodyAnti-Nmn/Namn Adenylyltransferase 1 antibodyAnti-Nicotinamide-Nucleotide Adenylyltransferase 1 antibodyAnti-Nmn Adenylyltransferase 1 antibodyAnti-Nicotinate-Nucleotide Adenylyltransferase 1 antibodyAnti-Namn Adenylyltransferase 1 antibodyAnti-NMNAT1 antibodyAnti-NMNAT antibody |
Information sourced from Uniprot.org
