Anti-NME1 antibody (C-Term) (STJ73079)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-NME1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 20+18kDa bands observed in lysates of cell lines A549, HeLa and HepG2 (calculated MW of 19.7kDa according to NP_937818.1 and 17.1kDa according to NP_000260.1). Recommended conc |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NME1 |
| Gene ID | 4830 |
| Uniprot ID | NDKA_HUMAN |
| Accession Number | NP_937818.1; NP_000260.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | DYTSCAQNWIYE |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_937818.1; NP_000260.1). |
Additional Info
| Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. |
| Protein Name | Nucleoside Diphosphate Kinase ANdk ANdp Kinase AGranzyme A-Activated DnaseGaadMetastasis Inhibition Factor Nm23Nm23-H1Tumor Metastatic Process-Associated Protein |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-9748787Reactome: R-HSA-9755088 |
| Cellular Localisation | CytoplasmNucleusCell-Cycle Dependent Nuclear Localization Which Can Be Induced By Interaction With Epstein-Barr Viral Proteins Or By Degradation Of The Set Complex By Gzma |
| Alternative Antibody Names | Anti-Nucleoside Diphosphate Kinase A antibodyAnti-Ndk A antibodyAnti-Ndp Kinase A antibodyAnti-Granzyme A-Activated Dnase antibodyAnti-Gaad antibodyAnti-Metastasis Inhibition Factor Nm23 antibodyAnti-Nm23-H1 antibodyAnti-Tumor Metastatic Process-Associated Protein antibodyAnti-NME1 antibodyAnti-NDPKA antibodyAnti-NM23 antibody |
Information sourced from Uniprot.org