• Immunohistochemistry analysis of NM23-H1 antibody in paraffin-embedded human brain tissue.
  • Western blot analysis of lysate from HeLa cells, uising NM23-H1 antibody.
  • Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:100 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
  • Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:100 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
  • Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:100 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
  • Western blot analysis of HeLa cells using NM23-H1 Polyclonal Antibody diluted at 1：1000
  • Western blot analysis of various cells using NM23-H1 Polyclonal Antibody diluted at 1：1000

Anti-NME1 antibody (3-52) (STJ94511)

SKU:
STJ94511

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Nucleoside diphosphate kinase A (3-52) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NME1
Gene ID: 4830
Uniprot ID: NDKA_HUMAN
Immunogen Region: 3-52
Specificity: NM23-H1 Polyclonal Antibody detects endogenous levels of NM23-H1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human NM23-H1. AA range:3-52
Tissue Specificity Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation.
Function Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Protein Name Nucleoside Diphosphate Kinase A
Ndk A
Ndp Kinase A
Granzyme A-Activated Dnase
Gaad
Metastasis Inhibition Factor Nm23
Nm23-H1
Tumor Metastatic Process-Associated Protein
Database Links Reactome: R-HSA-499943
Reactome: R-HSA-9748787
Reactome: R-HSA-9755088
Cellular Localisation Cytoplasm
Nucleus
Cell-Cycle Dependent Nuclear Localization Which Can Be Induced By Interaction With Epstein-Barr Viral Proteins Or By Degradation Of The Set Complex By Gzma
Alternative Antibody Names Anti-Nucleoside Diphosphate Kinase A antibody
Anti-Ndk A antibody
Anti-Ndp Kinase A antibody
Anti-Granzyme A-Activated Dnase antibody
Anti-Gaad antibody
Anti-Metastasis Inhibition Factor Nm23 antibody
Anti-Nm23-H1 antibody
Anti-Tumor Metastatic Process-Associated Protein antibody
Anti-NME1 antibody
Anti-NDPKA antibody
Anti-NM23 antibody

Information sourced from Uniprot.org

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